Drugs are an increasing worry for parents today. Drug abuse has a huge range of definitions related to taking a psychoactive drug or performance enhancing drug for a non-therapeutic or non-medical effect. All of these definitions imply a negative judgment of the drug use in question (compare with the term responsible drug use for alternative views). Many parents are concerned that their child will be offered illegal drugs or will begin to use them on a regular basis. Some of the drugs most often associated with this term include alcohol, amphetamines, barbiturates, benzodiazepines, cocaine, methaqualone, and opium alkaloids. Use of these drugs may lead to criminal penalty in addition to possible physical, social, and psychological harm, both strongly depending on local jurisdiction. Other definitions of drug abuse fall into four main categories: public health definitions, mass communication and vernacular usage, medical definitions, and political and criminal justice definitions.


Worldwide, the UN estimates there are more than 50 million regular users of heroin, cocaine and synthetic drugs.

There are ways that parents can help, you know your child better than anyone and this knowledge should be used as a basis for any help or support you give.


Potential for harm:


Depending on the actual compound, drug misuse including alcohol may lead to health problems, social problems, morbidity, injuries, unprotected sex, violence, deaths, motor vehicle accidents, homicides, suicides, mortality, physical dependence or psychological addiction.Drug abuse, including alcohol and prescription drugs can induce symptomatology which resembles mental illness. This can occur both in the intoxicated state and also during the withdrawal state. In some cases these substance induced psychiatric disorders can persist long after detoxification, such as prolonged psychosis or depression after amphetamine or cocaine abuse. A protracted withdrawal syndrome can also occur with symptoms persisting for months after cessation of use. Benzodiazepines are the most notable drug for inducing prolonged withdrawal effects with symptoms sometimes persisting for years after cessation of use. Abuse of hallucinogens can trigger delusional and other psychotic phenomena long after cessation of use and cannabis may trigger panic attacks during intoxication and with use it may cause a state similar to dysthymia. Severe anxiety and depression are commonly induced by sustained alcohol abuse which in most cases abates with prolonged abstinence. Even moderate alcohol sustained use may increase anxiety and depression levels in some individuals. In most cases these drug induced psychiatric disorders fade away with prolonged abstinence.


Drug abuse makes central nervous system (CNS) effects, which produce changes in mood, levels of awareness or perceptions and sensations. Most of these drugs also alter systems other than the CNS. Some of these are often thought of as being abused. Some drugs appear to be more likely to lead to uncontrolled use than others.


Traditionally, new pharmacotherapies are quickly adopted in primary care settings, however, drugs for substance abuse treatment have faced many barriers. Naltrexone, a drug originally marketed under the name "ReVia," and now marketed in intramuscular formulation as "Vivitrol" or in oral formulation as a generic, is a medication approved for the treatment of alcohol dependence. This drug has reached very few patients. This may be due to a number of factors, including resistance by Addiction Medicine specialists and lack of resources.


Legal approaches:


Most governments have designed legislation to criminalize certain types of drug use. These drugs are often called "illegal drugs" but generally what is illegal is their unlicensed production, distribution, and possession. These drugs are also called "controlled substances". Even for simple possession, legal punishment can be quite severe (including the death penalty in some countries). Laws vary across countries, and even within them, and have fluctuated widely throughout history.


Attempts by government-sponsored drug control policy to interdict drug supply and eliminate drug abuse have been largely unsuccessful. In spite of the huge efforts by the U.S., drug supply and purity has reached an all time high, with the vast majority of resources spent on interdiction and law enforcement instead of public health.[12][13] In the United States, the number of nonviolent drug offenders in prison exceeds by 100,000 the total incarcerated population in the EU, despite the fact that the EU has 100 million more citizens.


Despite drug legislation (and some might argue because of it), large, organized criminal drug cartels operate world-wide. Advocates of decriminalization argue that drug prohibition makes drug dealing a lucrative business, leading to much of the associated criminal activity.

Drug addiction:


Drug addiction is a pathological condition which arises due to frequent drug use. The disorder of addiction involves the progression of acute drug use to the development of drug-seeking behavior, the vulnerability to relapse, and the decreased, slowed ability to respond to naturally rewarding stimuli. The Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) has categorized three stages of addiction: preoccupation/anticipation, binge/intoxication, and withdrawal/negative affect. These stages are characterized, respectively, everywhere by constant cravings and preoccupation with obtaining the substance; using more of the substance than necessary to experience the intoxicating effects; and experiencing tolerance, withdrawal symptoms, and decreased motivation for normal life activities. By the American Society of Addiction Medicine definition, drug addiction differs from drug dependence and drug tolerance.

It is, both among scientists and other writers, quite usual to allow the concept of drug addiction to include persons who are not drug abusers according to the definition of the American Society of Addiction Medicine. The term drug addiction is then used as a category which may include the same persons who under the DSM-IV can be given the diagnosis of substance dependence or substance abuse.



Combined drug intoxication:



Combined Drug Intoxication or CDI, also known as Multiple Drug Intake (MDI), is an unnatural cause of human death. While it is sometimes reported as a simple "overdose", it is distinct in that it is due to the simultaneous use of multiple drugs, whether the drugs are prescription, over-the-counter, recreational, or some combination. The reasons for toxicity vary depending on the mixture of drugs.[citation needed]


CDI can occur with numerous drug combinations, including mixtures of over-the-counter (OTC) drugs, legally or illegally obtained prescription drugs, herbal mixtures, and home remedies. Ingestion of alcoholic beverages, in combination with other drugs, increases the risk of CDI.[citation needed]


The CDI/MDI phenomenon seems to be becoming more common in recent years. In December 2007, according to Dr. John Mendelson, a pharmacologist at the California Pacific Medical Center Research Institute, deaths by Combined Drug Intoxication were relatively "rare" ("one in several million") though they appeared then to be "on the rise".[1] In July 2008, the Associated Press and CNN reported on a medical study showing that over two decades from 1983 to 2004, such deaths have soared. It has also become a prevalent risk for older patients.


Risk factors:


People who engage in polypharmacy and other hypochondriac behaviors are at an elevated risk of death from CDI. Elderly people are at the highest risk of CDI, due to having many age related health problems requiring many medications combined with age-impaired judgment, leading to confusion in taking medications.


Recent veterans back from war and suffering from Post Traumatic Stress Disorder (PTSD) in combat are at risk of dying from CDI/MDI. Nine Veteran PTSD patients died from CDI/MDI in America in 2007. There are anecdotal reports of veterans dying from combinations of antidepressants, antipsychotics and tranquilizers used in combination with OTC medicines like Diphenhydramine.[citation needed] While still a U.S. senator from Illinois, United States President Barack Obama asked the U.S. Congress to inquire about the safety of these drugs.[citation needed] There is an ongoing investigation of the matter.



Prevention:


In general, the simultaneous use of multiple drugs should be carefully monitored by a qualified individual. Close association between prescribing physicians and pharmacies, along with the computerization of prescriptions and patients' medical histories, aim to avoid the occurrence of dangerous drug interactions. Lists of contraindications for a drug are usually provided with it, either in monographs or package inserts (accompanying prescribed medications) or in warning labels (for over-the-counter (OTC) drugs). CDI/MDI might also be avoided by physicians requiring their patients to return any unused prescriptions. Patients should ask their doctors and pharmacists if there are any interactions between the drugs they are taking.



Direct causes of death:


Combined Drug Intoxication can be caused by interactions between many different drugs.


CDI/MDI deaths often involve multiple CNS depressants, such as benzodiazepines (particularly strong hypnotics like temazepam, nitrazepam, or triazolam) and narcotic analgesics. Interactions between depressants may lead to severely depressed breathing or slowed heartbeat (bradycardia), causing the victim to become unconscious or comatose. While unconscious, the victim may regurgitate and die from asphyxia.


Certain drugs potentiate or amplify the effects of another drug and can lead to much stronger effects than either drug taken alone would produce; for example, Alcohol, a depressant, will potentiate the effects of other depressants and can cause respiratory depression and bradycardia; yet, because it is legal, easy to obtain, and commonly used, it may figure in about half of all MDI/CDI cases.[citation needed]


A CDI victim may have a drug-induced heart attack or heart failure. Multiple drug usage may weaken the human heart, and cause constipation or lower intestinal blockage, which may fail during constipated bowel movements. Many victims are found dead on their toilets. Some drugs may weaken the human immune system, making the patient susceptible to infections. It has been speculated that Howard Hughes may have died in such a manner.


The combination of OTC and prescription analgesics like NSAIDs and paracetamol(acetaminophen) can (potentially fatally) damage organs including the kidney, liver, and pancreas. Certain drug combinations can cause a mechanical interaction with blood, leading to excessive clotting. Clots may then travel into the heart, brain, or lungs and block blood flow, depriving tissue of oxygen and causing unconsciousness and then death (thrombosis).

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